WebApr 5, 2024 · In Wilms tumor, mutations in the ENL YEATS domain can promote the self-assembly of ENL via phase separation, resulting in the recruitment of SEC to promote oncogene expression and tumorigenesis (Wan et al., 2024; Figure 2). Thus, disease-related mutations in transcriptional regulators may be linked to phase separation models by … WebThe IDR/LCR of Ddx4 self-interacts to promote phase separation into protein-rich liquid-like droplets (Nott et al. 2015). The diverse functions of IDRs are not mutually exclusive, and IDRs that promote phase separation may also function as display sites and/or linker sequences. Phase separation requires the formation of many reversible ...
RNA buffers the phase separation behavior of prion-like RNA …
WebOct 4, 2024 · Membraneless compartments are often enriched with multivalent molecules that can form networks of interactions to promote phase separation . Such molecules include proteins with linear repeats of modular interaction domains. For example, ... Phase separation associated compartments or proteins can be identified with a high-throughput … WebNov 17, 2024 · Together, these data indicate that RNA is a strong modulator of TDP-43 phase separation, promoting fusion and coalescence into large droplets, depending on … google translate extension shortcut
Synergistic phase separation of two pathways promotes integrin …
WebAug 16, 2024 · TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics ... TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition. In live cells, TIA1 mutations delayed stress granule (SG) disassembly and promoted the … WebNov 3, 2024 · Phase separation is a process by which a well-mixed solution of macromolecules such as proteins or nucleic acids spontaneously separates into two … WebApr 12, 2024 · Low RNA/protein ratios promote phase separation into liquid droplets, whereas high ratios prevent droplet formation in vitro. Reduction of nuclear RNA levels or genetic ablation of RNA binding causes excessive phase separation and the formation of cytotoxic solid-like assemblies in cells. google translate finland to english