Klf4 phase separation

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August undefined, 2024

WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. … Web788 Likes, 28 Comments - Virginie Lascension (@virginie_lascension) on Instagram: "C’est une résurrection pour nous rendre meilleur. Une entrée dans une octave ...

Sequence-dependent surface condensation of a pioneer …

WebTo evaluate the role of KLF4 in cell-cycle progression, we silenced KLF4 by siRNAs in MCF-7 cells. FACS analysis showed a significant increase in the proportion of cells at S phase (Fig. 5E). Moreover, cell-proliferation analysis showed that silencing KLF4 promotes MCF-7 cell growth (Fig. 5F). Together the results indicate that KLF4 has an ... WebApr 11, 2024 · Phase separation of biomolecules occur to form membraneless compartments in response to extra- or intra-cellular stimuli. Recently, phase separation has been identified in different immune signaling pathways, of which cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is an important innate immune … rocher anime

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WebSep 22, 2024 · The study, published in the journal Nature Communications, reveals that the binding of KLF4 can cause DNA to condense into a separate liquid phase in a process … WebApr 12, 2024 · Hydrocyclones are widely used in the separation of two-phase immiscible mixtures. In various application scenarios, three-phase hydrocyclones (3PH) are often urgently needed. In this work, the typical 3PHs are classified into six categories according to their structural characteristics. A comprehensive analysis of their structural feature ... WebNational Center for Biotechnology Information rocher architecte

KLF4 suppresses transformation of pre-B cells by ABL oncogenes

Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat ...

WebAug 26, 2024 · Admittedly, phase separation is a young biological research direction, and many problems persist to overcome how to precisely regulate phase separation, such as … WebHere we investigate the role of DNA in nucleation of condensates, using the pioneer transcription factor KLF-4. We show that KLF-4 forms liquid-like condensates on the DNA … rocher ananasWebApr 13, 2024 · Many proteins undergo a process of phase separation that leads to the formation of biomolecular condensates. It has been observed that some of these proteins form dense droplets of sizeable dimensions already below their critical concentration for phase separation. To understand this phenomenon, which is not readily compatible with … rocher animal crossing

"WebJun 18, 2024 · KLF4 represses transcription of the EGFR gene, leading to reduced levels of total EGFR, its activated/phosphorylated form (pEGFR), and its downstream signaling intermediates. Moreover, KLF4 suppression of EGFR is a necessary intermediary step for KLF4 to inhibit aggressive TNBC phenotypes. " - Klf4 phase separation

Klf4 phase separation

Liquid condensation of reprogramming factor KLF4 with DNA

WebKlf4 forms phase separated condensates in vitro. a, SDS gel showing recombinantly expressed and purified MBP-Klf4-GFP. b, Test of the affinity of Klf4-GFP to short dsDNA … WebFeb 14, 2024 · Phase separation of proteins/nucleic acids to form non-membrane organelles is crucial in cellular gene-expression regulation. However, little is known about …

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WebSep 22, 2024 · KLF4 is thought to induce long-range pluripotency contacts through condensation at promoters of pluripotency factors (Sharma et al. 2024 ). However, KLF4 condensation depends on KLF4-DNA... WebHere we investigate the role of DNA in nucleation of condensates, using the pioneer transcription factor KLF-4. We show that KLF-4 forms liquid-like condensates on the DNA …

WebMar 23, 2024 · The evident changes observed in cell morphology together with the downregulation of the naïve pluripotency markers Nanog, Klf4 and Esrrb and the increase of the mRNA levels of primed... WebApr 4, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.

WebApr 3, 2024 · Gliomas, accounting for ~25% of primary CNS tumors, have an average mortality rate of 4.43 per 100,000 and 16,606 deaths per year [1, 2].Standard therapies of surgery resection combined with ... WebOct 19, 2016 · The newt RPE has also been studied with respect to the molecular mechanism of cell entry into the S-phase after RPE separation from the NR [62,63]. The authors of the first study analyzed an activity of MEK-ERK signaling in RPE just after NR removal from the newt eye and found it activated within 30 min after retinectomy. ... Mitf, …

WebLiquid–liquid phase separation is a fundamental biophysical process to organize eukaryotic and prokaryotic cytosols. While many biomolecular condensates are formed in the vicinity of, or even...

WebAug 28, 2013 · KLF4, as a member of KLF family, expresses in a wide range of tissues in mammals, and plays a critical role in regulating a diverse array of cellular processes … rocher auditionWebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). rocher badonWebFeb 3, 2024 · We show that Klf4 can phase separate on its own at high concentrations, but at low concentrations, Klf4 only forms condensates on DNA. Using optical tweezers, we … rocher archicadWebDec 26, 2024 · In agreement with this, Klf4 overexpression reduced cell viability, increased the fraction of apoptotic cells, and arrested cell cycle progression in G1 phase. We conclude that Klf4 increases the susceptibility of preovulatory GCs to apoptosis by down-regulating Bcl-2, and promotes LH-induced cell cycle exit. It appears to be a key regulator ... rocher autocadWebDec 7, 2024 · KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by … rocher aphrodite chypre rocher architectureWebDec 21, 2024 · Phase separation Germ granules are the earliest known and most studied phase-separated membrane-less organelles in germ cells during early embryonic … rocher ardèche 07