Web1 dec. 2013 · The release of IL-1beta in response to nigericin, a potassium ionophore, and maitotoxin, a potent marine toxin, was also found to be dependent on cryopyrin. In contrast to Asc-/- macrophages, cells deficient in the gene encoding cryopyrin (Cias1-/-) activated caspase-1 and secreted normal levels of IL-1beta and IL-18 when infected with Gram … Web21 okt. 2024 · Nigericin, another mobile carrier, left both isoforms unaffected. The membrane-integral pore-forming gramicidin evenly inhibited TbAQP2 and TbAQP2 in the …
Intracellular pH Modulates Autophagy and Mitophagy
Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebWell-known ionophore-antibiotics include Valinomycin, Gramicidin, Nigericin, Monensin and Monactin, which kill cells by altering ionic gradients. Valinomycin specifically transports potassium while others transports monovalent cations such as sodium, potassium, hydrogen and ammonium ions. dark and golden choc ice
Potential SARS-CoV-2 antiviral: Ionophore X-206 found to inhibit …
WebToxins 2013, 5 1168 control of serum-response element (SRE). All dermonecrotic toxins carry a glutamine deamidase activity at their C-terminus that activates their G-protein target substrates and use their N-terminus as the machinery for binding to cells and facilitating membrane translocation of their cargo (activity WebNigericin has been employed to study anion transport (Section 2.5) and to modify the pH gradient across energy-conserving membranes. It is often stated that nigericin abolishes ΔpH across a membrane; in fact, the ionophore equalises the K + and H + concentration gradients, with the final ion gradients depending on the experimental conditions. WebNigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes to phytohemagglutinin (PHA). Inhibition occurred at nigericin concentrations of 10 (-8) M or greater, and only during the early event of mitogenesis. birth year for millennial