Webhematoma formation, AQP-4 expression, and neurological outcomes after ICH associated with hyperglycemia in a rat model of ICH. Materials and Methods Animals All animal experimental protocols were in compliance with the regu-lations of the Animal Welfare Committees of the Academic Sinica, Taipei, Taiwan. WebOct 15, 2011 · AQP-4 is up-regulated in GBM , its distribution is not restricted to astrocytic endfeet , and its up-regulation in tumor cells and reactive astrocytes surrounding gliomas plays a role in vasogenic edema formation. AQP-4 over-expression in human astrocytoma correlates with the presence of brain edema on magnetic resonance imaging , .
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