Fam72a antagonizes ung2
WebJ:326431 Feng Y, et al., FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2024 Dec;600(7888):324-328) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology … WebFeb 1, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Nature 2024. 600(7888):324-328. (PMID: 34819670) Abstract Full Text Link. Sherker A, Chaudhary N, Adam S, Noordermeer SM, Fradet-Turcotte, Durocher D. Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites
Fam72a antagonizes ung2
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WebMar 3, 2024 · FAM72A-D promote the self-renewal of neural progenitor cells. There is accumulating evidence that FAM72 promotes tumorigenicity. However, its effects in lung … WebSeveral studies indicated that FAM72A functions by interacting with uracil DNAglycosylase 2 (UNG2), a crucial enzyme in base excision repair (BER), catalyzing the replacement of deoxyuracil (dU ...
WebNov 24, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Article Publication Date. 24-Nov-2024. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ... WebDec 9, 2024 · Request PDF FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Activation-induced cytidine deaminase (AID) catalyses the …
WebIn the present study, we determined a specific FAM72A-UNG2 heterodimer protein interaction using molecular docking and dynamics. In addition, through in silico screening, we identified withaferin B as a molecule that can specifically prevent the FAM72A-UNG2 interaction by blocking its cell signaling pathways. Our results provide an excellent ... WebNov 24, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. FAM72A differentially controls mutation rates by regulating uracil processing …
WebNov 25, 2024 · So far, the detailed molecular mechanism by which FAM72a antagonizes UNG2 remains to be determined. We are putting efforts into systematically analyzing the molecular interplay between FAM72a with UNG2, and how exactly the binding of FAM72a regulates UNG2 stability and activity. 5:30 p.m. Presenter: Miss Yan LI, MPhil candidate
WebAug 1, 2024 · Yet, the mechanisms by which FAM72A regulates UNG2 degradation is an open question. It has been suggested that different genetic loci might exhibit different … freshman shepherd university dormsWebMar 26, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Title: FAM72A antagonizes UNG2 to promote mutagenic repair during … fat face helmsleyWeb影响因子：9.685. 合作单位：上海交通大学医学院附属第九人民医院. 中科新生命提供的服务内容：靶向色氨酸代谢. # 06. 文献名称：Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy. 发表期刊：Diabetes. 影响因子：9.337. 合作单位：贵州 ... freshman shirtsWebMar 2, 2024 · Fu et al. find a cell cycle gene, Fam72a, that supports cell proliferation, antagonizes apoptosis, and controls tubulin and Mcl-1 phosphorylation during the G2/M … freshman showcaseWebDec 9, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. FAM72A differentially controls mutation rates by regulating uracil processing at different stages of the cell cycle ... freshman shs meaning feuWebAug 1, 2024 · Yet, the mechanisms by which FAM72A regulates UNG2 degradation is an open question. It has been suggested that different genetic loci might exhibit different susceptibilities to mutagenic BER, ... FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature, 600 (2024), pp. 324-328. CrossRef View … fat face hedgehog hand warmerWebThe somatic hypermutation spectrum in B cells from Fam72a−/− mice is opposite to that observed in mice deficient in uracil DNA glycosylase 2 (UNG2)7, which suggests that … fat face henley t shirt